Hb Toyoake: beta 142 (H20) Ala replaced by Pro. A new unstable hemoglobin with high oxygen affinity
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Hemoglobin Crete ( fi 129 Ala - k Pro ) : A New High - Affinity Variant Interacting With $ # { 176 } -
Hemoglobin Crete, 1 29 (H7) ala -k pro, is #{149} new mutant hemoglobin (Hb) with high oxygen affinity that was discovered in a Greek family in various combinations with #{176}and #{244} ’-thaIassemia. The propositus. who presented an unusual clinical picture of an “overcompenseted” hemolytic state. with erythrocytosis. splenomegaly. abnormal red cell morphology, and marked erythroid hyperplasi...
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A patient with a normal blood hemoglobin was found to be heterozygous for a new level, but with evidence of brisk hemolfl-chain mutation and fl-thalassemia. All ysis, was found to have an unstable of the hemoglobin in his red cells was of hemoglobin with a left-shifted oxygen the abnormal type, designated hemodissociation curve. Two sisters of the paglobin Duarte, and was shown to contain tient...
متن کاملA New High - Oxygen - Affinity Mutant Human Hemoglobin
The functional properties and primary in the 144 position of the fl-chain, structure of a new $-chain mutant of a fl ” ’ ”, presumably due to an human hemoglobin are described. The AAA/G to AAA/U transversion. The mumutant was transmitted as an autosomal tant hemoglobin displayed a profound indominant characteristic. Affected memcrease in oxygen affinity, with a P o of the bars of the kindred e...
متن کاملHb Potomac (101 Glu replaced by Asp): speculations on placental oxygen transport in carriers of high-affinity hemoglobins.
Blood from a woman with unexplained erythrocytosis had increased oxygen affinity, but no abnormality could be detected by electrophoresis or chromatography of her hemolysate. Separation of the tryptic peptides of her beta chains disclosed two half-sized peaks in the regions of beta T-11. The faster of these was abnormal, with the structure beta 101 Glu replaced by Asp. The new hemoglobin was ca...
متن کاملAnaesthesia in a patient with subarachanoidal haemorrhage and high oxygen affinity haemoglobinopathy (HB york): case report
BACKGROUND Approximately 90 haemoglobinopathies have been identified that result in abnormally high oxygen affinity. One of these is haemoglobinopathy York (HbY), first described in 1976. HbY causes an extreme leftward shift of the oxygen dissociation curve with the P50 value changing to 12.5 - 15.5 mmHg (normal value 26.7 mmHg), indicating that approximately half of the haemoglobin is not avai...
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ژورنال
عنوان ژورنال: Blood
سال: 1981
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v57.4.697.bloodjournal574697